Experimental Investigation of Pulsatility Effect on the Deformability and Hemolysis of Blood Cells
| Autor: | Myounggon Kim, Hyuk-Sang Kwon, Kuk Hui Son, Choon Hak Lim, Sung Yang, Ho Sung Son, Yang Jun Kang, Sang Youl Yoon |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Erythrocytes Biomedical Engineering Pulsatile flow Medicine (miscellaneous) Bioengineering Hemolysis Statistics Nonparametric law.invention Biomaterials Random Allocation Dogs law Erythrocyte Deformability Internal medicine Image Processing Computer-Assisted medicine Cardiopulmonary bypass Animals Operation time Pulsatile perfusion Cardiopulmonary Bypass business.industry Significant difference General Medicine medicine.disease Pulsatile Flow Immunology Cardiology Hemoglobin business Perfusion circulatory and respiratory physiology |
| Zdroj: | Artificial Organs. 34:E103-E109 |
| ISSN: | 1525-1594 0160-564X |
| DOI: | 10.1111/j.1525-1594.2009.00974.x |
| Popis: | In this study, we investigated the differences between pulsatile cardiopulmonary bypass (CPB) procedure and nonpulsatile CPB procedure in terms of their effects on hemolysis and deformability of red blood cells (RBCs) under various shear stress conditions. In order to research the effects on hemolysis and deformability, four parameters--free hemoglobin (fHb) concentration, normalized index of hemolysis (NIH), deformability index (DI) of RBCs, and elongation index of RBCs--have been deeply investigated. For these investigations, two randomly assigned adult mongrel dog groups-nonpulsatile group (NP, n = 6) and pulsatile group (P, n = 6)--were examined. According to our results, both types of perfusion did not show any statistical differences in terms of the concentrations of fHb as well as NIH. In addition, there were no significant differences in RBC deformability between perfusion types within an operation time of 3 h. Therefore, our studies suggest that pulsatile perfusion has no significant difference from nonpulsatile perfusion in terms of hemolysis and deformability of RBCs. |
| Databáze: | OpenAIRE |
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