Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
| Autor: | Lizhu Chen, Weien Yuan, Xiaoyun Hong, Zhenguo Liu, Liangming Wei, Fei Wu, Zaozhan Wu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Drug
Sustained delivery media_common.quotation_subject Pharmaceutical Science Economic shortage Review Pharmacology Administration Cutaneous microneedle Delayed-Action Preparations Drug Delivery Systems dissolving Absorbable Implants Drug Discovery Animals Humans Medicine sustained release media_common Transdermal Hypodermic needle Vaccines business.industry Equipment Design Solubility Needles Drug delivery biodegradable business Biomedical engineering |
| Zdroj: | Drug Design, Development and Therapy |
| ISSN: | 1177-8881 |
| DOI: | 10.2147/dddt.s44401 |
| Popis: | Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|