Acute Kidney Injury in Monoclonal Gammopathies
| Autor: | Francescaromana Festuccia, Silvia Lai, Paolo Menè, Antonella Stoppacciaro, Alessandra Moioli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty immunoglobulins Renal function Review urologic and male genital diseases Nephropathy medicine acute kidney injury monoclonal gammopathies multiple myeloma light chains hemodialysis Multiple myeloma Kidney urogenital system business.industry Acute kidney injury Glomerulonephritis General Medicine medicine.disease Tumor lysis syndrome medicine.anatomical_structure Monoclonal Medicine business |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 3871, p 3871 (2021) Journal of Clinical Medicine |
| Popis: | Monoclonal gammopathies (MG) encompass a variety of disorders related to clonal expansion and/or malignant transformation of B lymphocytes. Deposition of free immunoglobulin (Ig) components (light or heavy chains, LC/HC) within the kidney during MG may result over time in multiple types and degrees of injury, including acute kidney injury (AKI). AKI is generally a consequence of tubular obstruction by luminal aggregates of LC, a pattern known as “cast nephropathy”. Monoclonal Ig LC can also be found as intracellular crystals in glomerular podocytes or proximal tubular cells. Proliferative glomerulonephritis with monoclonal Ig deposits is another, less frequent form of kidney injury with a sizable impact on renal function. Hypercalcemia (in turn related to bone reabsorption triggered by proliferating plasmacytoid B cells) may lead to AKI via functional mechanisms. Pharmacologic treatment of MG may also result in additional renal injury due to local toxicity or the tumor lysis syndrome. The present review focuses on AKI complicating MG, evaluating predictors, risk factors, mechanisms of damage, prognosis, and options for treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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