Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project
| Autor: | Elisabetta Poluzzi, Gianluca Trifirò, Giuseppe Boriani, M. A. J. de Ridder, Serena Pecchioli, F. De Ponti, Ariola Koci, Irene D. Bezemer, Tania Schink, Alessandro Oteri, M. Clo, S. Pilgaard Ulrichsen, M C J M Sturkenboom, Igor Diemberger |
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| Přispěvatelé: | Medical Informatics, Poluzzi, Elisabetta, Diemberger, I., De Ridder, M., Koci, A., Clo, M., Oteri, A., Pecchioli, S., Bezemer, I., Schink, T., Pilgaard Ulrichsen, S., Boriani, G., Sturkenboom, M. C. J., De Ponti, F., Trifirã², G. |
| Rok vydání: | 2017 |
| Předmět: |
Male
Ebastine 030204 cardiovascular system & hematology Loratadine Antihistamine Levocetirizine 0302 clinical medicine Antihistamines Arrhythmia Case-control study Drug safety Healthcare databases Aged Case-Control Studies Europe Female Histamine Antagonists Humans Middle Aged Odds Ratio Risk Tachycardia Ventricular Pharmacology Pharmacology (medical) Tachycardia Terfenadine DRUG Desloratadine General Medicine HYDROXYZINE SAFETY Anesthesia Cohort HEART medicine.drug medicine.medical_specialty Healthcare database 03 medical and health sciences Internal medicine medicine INTERVAL business.industry Ventricular QT PROLONGATION Odds ratio Nested case-control study business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Clinical Pharmacology, 73(11), 1499-1510. Springer-Verlag European Journal of Clinical Pharmacology, 73(11), 1499. Springer Verlag Poluzzi, E, Diemberger, I, De Ridder, M, Koci, A, Clo, M, Oteri, A, Pecchioli, S, Bezemer, I, Schink, T, Ulrichsen, S P, Boriani, G, Sturkenboom, M C J, De Ponti, F & Trifiro, G 2017, ' Use of antihistamines and risk of ventricular tachyarrhythmia : a nested case-control study in five European countries from the ARITMO project ', European Journal of Clinical Pharmacology, vol. 73, no. 11, pp. 1499-1510 . https://doi.org/10.1007/s00228-017-2317-0 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-017-2317-0 |
| Popis: | Purpose: After regulatory restrictions for terfenadine and astemizole in ‘90s, only scarce evidence on proarrhythmic potential of antihistamines has been published. We evaluate the risk of ventricular tachyarrhythmia (VA) related to the use of individual antihistamines. Methods: A matched case-control study nested in a cohort of new users of antihistamines was conducted within the EU-funded ARITMO project. Data on 1997–2010 were retrieved from seven healthcare databases: AARHUS (Denmark), GEPARD (Germany), HSD and ERD (Italy), PHARMO and IPCI (Netherlands) and THIN (UK). Cases of VA were selected and up to 100 controls were matched to each case. The odds ratio (OR) of current use for individual antihistamines (AHs) was estimated using conditional logistic regression. Results: For agents largely used to prevent allergic symptoms, such as cetirizine, levocetirizine, loratadine, desloratadine and fexofenadine, we found no VA risk. A statistically significant, increased risk of VA was found only for current use of cyclizine in the pooled analysis (ORadj, 5.3; 3.6–7.6) and in THIN (ORadj, 5.3; 95% CI, 3.7–7.6), for dimetindene in GEPARD (ORadj, 3.9; 1.1–14.7) and for ebastine in GEPARD (ORadj, 3.3; 1.1–10.8) and PHARMO (ORadj, 4.6; 1.3–16.2). Conclusions: The risk of VA associated with a few specific antihistamines could be ascribable to heterogeneity in pattern of use or in receptor binding profile. |
| Databáze: | OpenAIRE |
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