Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis
| Autor: | Kaei Nasu, Hisashi Narahara, Akitoshi Yuge, Akitoshi Tsuno |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Simvastatin
medicine.medical_specialty Stromal cell Endometriosis In Vitro Techniques Contractility Fibrosis Internal medicine polycyclic compounds Humans Medicine Cells Cultured biology business.industry Cell growth nutritional and metabolic diseases Obstetrics and Gynecology medicine.disease Hydroxymethylglutaryl-CoA reductase Endocrinology Reproductive Medicine HMG-CoA reductase biology.protein Cancer research Female Collagen Hydroxymethylglutaryl-CoA Reductase Inhibitors Stromal Cells business Cell Division medicine.drug |
| Zdroj: | Fertility and Sterility. 92:2097-2099 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2009.06.055 |
| Popis: | Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis. |
| Databáze: | OpenAIRE |
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