Adipocytokines and their relationship to endometrial cancer risk: A systematic review and meta-analysis
Autor: | Gemma A. Barron, Patricia E. Ellis, Giovanna Bermano |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Leptin medicine.medical_specialty Adipokine Gastroenterology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Carcinoma Humans Adiponectin business.industry Interleukin-6 Tumor Necrosis Factor-alpha Endometrial cancer Obstetrics and Gynecology Cancer Odds ratio medicine.disease Obesity Endometrial Neoplasms 030104 developmental biology Oncology 030220 oncology & carcinogenesis Case-Control Studies Female business |
Zdroj: | Gynecologic oncology. 158(2) |
ISSN: | 1095-6859 |
Popis: | Objective:- To investigate the association between circulating levels of adipocytokines (adiponectin, leptin, tumour necrosis factor alpha (TNFα), interleukin 6 (IL-6)) and growth factors (insulin-like growth factor I (IGF-I) and II (IGF-II)), and the risk of endometrial cancer. Methods:- Cochrane, CINAHL, Embase, Medline and Web of Science were searched for English-language manuscripts published between January 2000 and August 2018 using the following string of words: cancer and endometrial and (obesity or BMI) and (adiponectin or TNF* or IGF-I or IGF-II or IL-6 or leptin). Results:- Twenty articles were included in this meta-analysis, which corresponded to 18 studies involving 2921 endometrial carcinoma cases and 5302 controls. Fourteen articles reported circulating levels for adiponectin, seven for leptin, three for TNFα, three for IL-6 and one for IGF- I. No article reported values for IGF- II. Patients with circulating adiponectin levels in the highest tertile had decreased endometrial cancer risk compared to women with levels in the lowest tertile, (summary of odds ratio (SOR) 0.51, 95% CI: 0.38-0.69, p[less than]0.00001). Women with circulating leptin concentrations in the highest tertile had increased endometrial cancer risk compared to women with concentrations in the lowest tertile (SOR 2.19, 95% CI: 1.45-3.30, p=0.0002). There was no difference in cancer risk between participants with the highest TNFα and IL-6 levels compared to the lowest levels (SOR 1.27, 95% CI: 0.88-1.83, p=0.20 and SOR 1.20, 95% CI: 0.89-1.63, p=0.23, respectively). Conclusions:- Endometrial cancer risk is inversely affected by adiponectin and leptin levels. There appears to be no relationship between TNF-α and IL- 6 and the overall risk of endometrial cancer. |
Databáze: | OpenAIRE |
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