Salivary concentrations of macrophage activation-related chemokines are influenced by non-surgical periodontal treatment: a 12-week follow-up study

Autor: Eija Könönen, Maria Anastasia Grande, Christian Kroun Damgaard, Ulvi Kahraman Gursoy, Daniel Belstrøm, Mervi Gürsoy, Palle Holmstrup
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Grande, M A, Belstrøm, D, Damgaard, C, Holmstrup, P, Könönen, E, Gursoy, M & Gursoy, U K 2020, ' Salivary concentrations of macrophage activation-related chemokines are influenced by non-surgical periodontal treatment : a 12-week follow-up study ', Journal of Oral Microbiology, vol. 12, no. 1, 1694383 . https://doi.org/10.1080/20002297.2019.1694383
Journal of Oral Microbiology
ISSN: 2000-2297
DOI: 10.1080/20002297.2019.1694383
Popis: Background: During periodontal inflammation, bacteria induces chemokine expression and migration of various inflammatory cells. The aim of the study was to learn if periodontal treatment alters salivary concentrations of macrophage activation-related chemokines and if such alterations correlate with abundance of periodontitis-associated bacteria. Methods: Twenty-five patients with periodontitis completed the study (NCT02913248 at clinicaltrials.gov). Periodontal parameters and stimulated saliva samples were obtained at baseline and 2, 6 and 12 weeks after non-surgical periodontal treatment. Salivary concentrations of monocyte chemoattractant proteins (MCP-1-4), macrophage-derived chemokine (MDC), macrophage migration inhibitory factor (MIF), monokine induced by interferon-gamma (MIG), macrophage inflammatory protein (MIP-1α) and interferon-inducible protein (IP-10) were quantified using the Luminex® xMAP™ technique and abundance of bacteria was quantified using next-generation sequencing. Results: The treatment improved all periodontal parameters and caused an increase in the concentrations of MCP-2, MDC and MIP-1α at week 12 compared to baseline, week 2 and week 6, respectively. Salivary concentrations of MCP-1-2, MDC, MIG, MIP-1α and IP-10 correlated with the abundance of specific periodontitis-associated bacteria. Conclusions: Periodontal treatment impacts salivary concentrations of MCP-2, MDC and MIP-1α, which correlate with the abundance of specific periodontitis-associated bacteria. This indicates that these chemokines reflect periodontal status and possess potential in illustrating a response to treatment.
Databáze: OpenAIRE
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