Norwalk virus antigen and antibody response in an adult volunteer study
| Autor: | Philip C Johnson, A. V. Bartlett, Herbert L. DuPont, G W Gary, Larry J. Anderson, B. H. Keswick, S. E. Stine |
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| Rok vydání: | 1987 |
| Předmět: |
Microbiology (medical)
viruses Biology Antibodies Viral Virus Disease Outbreaks Feces Antigen medicine Humans Seroconversion Antigens Viral Immunoassay medicine.diagnostic_test Antibody titer Outbreak biology.organism_classification Virology Gastroenteritis Norwalk virus Specimen collection Virus Diseases Acute Disease Immunology Research Article |
| Zdroj: | Journal of Clinical Microbiology. 25:2001-2003 |
| ISSN: | 1098-660X 0095-1137 |
| Popis: | To better define the optimum timing of specimen collection and identify alternate ways to diagnose Norwalk virus outbreaks, we looked at the timing of the antibody response and virus excretion in a human volunteer study. The Norwalk virus antibody titers and antigen in stool specimens were examined by biotin-avidin immunoassay. Our data suggest that in epidemic situations, convalescent-phase sera could be collected as soon as 13 days after the onset of illness and acute-phase sera could be collected as late as 5 days after onset. Our data also suggest that if sufficient serum samples are collected, convalescent-phase case and control serum samples can be used to identify Norwalk virus outbreaks. Antigen detection was much less sensitive than seroconversion for detecting infection. |
| Databáze: | OpenAIRE |
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