Educational Case: Endocrine Neoplasm
| Autor: | Sheila E. Segura, Mark J. Suhrland, Gloria Ramos-Rivera |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty endocrine system clinical features cytologic diagnosis Medullary cavity endocrine system diseases 030209 endocrinology & metabolism endocrine neoplasms Pathology and Forensic Medicine Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine medullary thyroid carcinoma Solitary thyroid nodule medicine lcsh:Pathology pathologic features Multiple endocrine neoplasia business.industry organ system pathology Thyroid Medullary thyroid cancer Educational Case medicine.disease molecular basis medicine.anatomical_structure 030220 oncology & carcinogenesis Endocrine neoplasm pathology competencies business Familial medullary thyroid cancer lcsh:RB1-214 |
| Zdroj: | Academic Pathology, Vol 5 (2018) Academic Pathology |
| ISSN: | 2374-2895 |
| Popis: | Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance. This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma. |
| Databáze: | OpenAIRE |
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