| Autor: |
Simon T. Barry, Stephen Green, Marie Cumberbatch, Emily Foster, Elizabeth A. Harrington, Barry R. Davies, Mandy Lawson, Steve Powell, Lara Ward, Stephen R. Wedge, Lillian Castriotta, Celina D'Cruz, Donald Ogilvie, Paul D. Smith, Martina Fitzek, Bernard Barlaam, Claire Crafter, Hannah Dry, Rebecca Ellston, Carol Lenaghan, Cath Trigwell, Lyndsey Hanson, Sabina Cosulich, Urs Hancox |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1535-7163.22502407.v1 |
| Popis: |
Supplementary Tables 1-3 and Figure 1-7. Supp Table 1 Summary of cell line origins and verification. Supp Table 2 Summary of antibodies used in all experimental analysis Supp Fig 1 AZD8186 inhibits PI3K pathway in PTEN null but not PTEN WT PIKC3A MT cells Supp Fig 2 AZD8186 inhibits LPA, EGF and rac dependent Ser473 AKT phosphorylation in serum starved prostate and breast cancer cells Supp Fig 3 Western blot analysis of showing induction of FOXO3a association with the chromatin fraction following treatment with AZD8186 Supp Fig 4 AZD8186 inhibits proliferation in a subset of cancer cell lines Supp Table 3 GI50 of all cell lines showing sensitivity to AZD8186 Supp Fig 5 Western blot protein analysis of PTEN status across a panel of breast and prostate cell lines Supp Fig 6 Pathway biomarker suppression in PC3 and HID28 tumours Supp Fig 7 AZD8186 selectively suppresses pathway biomarkers in tumour versus lung |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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