Fatty acid transport into the brain: Of fatty acid fables and lipid tails
| Autor: | Ryan W. Mitchell, Grant M. Hatch |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Clinical Biochemistry
Drug delivery to the brain Biology Tight Junctions chemistry.chemical_compound Biosynthesis Free fatty acid receptor 1 Extracellular Animals Humans Phospholipids chemistry.chemical_classification Sphingolipids Tight junction Cell Membrane Fatty Acids Endothelial Cells Fatty acid Biological Transport Biological membrane Cell Biology Sphingolipid chemistry Biochemistry Blood-Brain Barrier Cerebrovascular Circulation |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 85:293-302 |
| ISSN: | 0952-3278 |
| Popis: | The blood-brain barrier formed by the brain capillary endothelial cells provides a protective barrier between the systemic blood and the extracellular environment of the central nervous system. Brain capillaries are a continuous layer of endothelial cells with highly developed tight junctional complexes and a lack of fenestrations. The presence of these tight junctions in the cerebral microvessel endothelial cells aids in the restriction of movement of molecules and solutes into the brain. Fatty acids are important components of biological membranes, are precursors for the biosynthesis of phospholipids and sphingolipids and are utilized for mitochondrial β-oxidation. The brain is capable of synthesizing only a few fatty acids. Hence, most fatty acids must enter into the brain from the blood. Here we review current mechanisms of transport of free fatty acids into cells and describe how free fatty acids move from the blood into the brain. We discuss both diffusional as well as protein-mediated movement of fatty acids across biological membranes. |
| Databáze: | OpenAIRE |
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