Transmission of Avian Influenza Virus (H3N2) to Dogs
| Autor: | Jinsik Oh, Bong-Kyun Park, Chul Seung Lee, Seong-Jun Park, Bo-Kyu Kang, Gun-Woo Ha, Daesub Song, Kwonil Jung, Dong Seok Kang |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Epidemiology Canine influenza viruses lcsh:Medicine Receptors Cell Surface macromolecular substances Biology medicine.disease_cause H5N1 genetic structure Virus Poultry influenza virus lcsh:Infectious and parasitic diseases Dogs Orthomyxoviridae Infections Species Specificity South Korea Veterinary virology Influenza A virus medicine Animals lcsh:RC109-216 Dog Diseases research Transmission (medicine) avian musculoskeletal neural and ocular physiology Influenza A Virus H3N2 Subtype lcsh:R virus diseases H3N2 Virology Influenza A virus subtype H5N1 Infectious Diseases nervous system Influenza in Birds dog Transmission and infection of H5N1 |
| Zdroj: | Emerging Infectious Diseases, Vol 14, Iss 5, Pp 741-746 (2008) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Infection with and transmission of the virus was identified in pet dogs with severe respiratory disease. In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. To determine whether the novel canine influenza virus of avian origin was transmitted among dogs, we experimentally infected beagles with this influenza virus (H3N2) isolate. The beagles shed virus through nasal excretion, seroconverted, and became ill with severe necrotizing tracheobronchitis and bronchioalveolitis with accompanying clinical signs (e.g., high fever). Consistent with histologic observation of lung lesions, large amounts of avian influenza virus binding receptor (SAα 2,3-gal) were identified in canine tracheal, bronchial, and bronchiolar epithelial cells, which suggests potential for direct transmission of avian influenza virus (H3N2) from poultry to dogs. Our data provide evidence that dogs may play a role in interspecies transmission and spread of influenza virus. |
| Databáze: | OpenAIRE |
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