Bortezomib may be safely combined with Y-90-ibritumomab tiuxetan in patients with relapsed/refractory follicular non-Hodgkin lymphoma: a phase I trial of combined induction therapy and bortezomib consolidation
| Autor: | Jeffrey Cilley, L. Gallot, Alfred Rademaker, Annette Larson, Daina Variakojis, Jane N. Winter, Rupali Roy, Stewart Spies, David Patton, Andrew M. Evens, Leo I. Gordon |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Neutropenia medicine.medical_treatment Follicular lymphoma Ibritumomab tiuxetan Antineoplastic Agents Drug Administration Schedule Bortezomib Refractory Recurrence hemic and lymphatic diseases Internal medicine Follicular phase medicine Humans Yttrium Radioisotopes Aged Cardiotoxicity Dose-Response Relationship Drug business.industry Lymphoma Non-Hodgkin Antibodies Monoclonal Hematology Induction Chemotherapy Middle Aged Radioimmunotherapy medicine.disease Boronic Acids Combined Modality Therapy Surgery Lymphoma Treatment Outcome Drug Resistance Neoplasm Pyrazines Female business medicine.drug Follow-Up Studies |
| Zdroj: | Leukemialymphoma. 54(3) |
| ISSN: | 1029-2403 |
| Popis: | Preclinical studies suggest that bortezomib, through inhibition of nuclear factor-κB (NF-κB) activation, may enhance the effects of radioimmunotherapy. This phase I trial was designed to determine the maximum tolerated dose (MTD) of weekly bortezomib induction combined with Y-90-ibritumomab tiuxetan followed at the time of count recovery by weekly bortezomib consolidation in patients with relapsed/refractory follicular or transformed non-Hodgkin lymphoma. Grade 3 or 4 toxicities were observed in eight of nine treated patients, and all but one of these toxicities were hematologic. One patient had grade 3 cardiotoxicity. A dose limiting toxicity (DLT) of grade 4 thrombocytopenia was observed in two of three patients treated with bortezomib at 1.6 mg/m(2), resulting in a MTD of 1.3 mg/m(2). The overall response rate was 89% (two complete response [CR], six partial response [PR], one stable disease [SD]), with a median progression-free survival of 6.5 months (range: 3-22.5+ months). A phase II trial at the MTD is under way to better define the toxicity and effectiveness of this regimen. |
| Databáze: | OpenAIRE |
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