Zirconium Catalyzed Hydroaminoalkylation for the Synthesis of α-Arylated Amines and N-Heterocycles
| Autor: | Laurel L. Schafer, Ana Koperniku |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Steric effects
chemistry.chemical_classification Zirconium 010405 organic chemistry Chemistry Alkene Organic Chemistry Substrate (chemistry) chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Amine gas treating |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 27(20) |
| ISSN: | 1521-3765 |
| Popis: | The zirconium catalyzed hydroaminoalkylation of alkenes with N-aryl- and sterically demanding N-alkyl-α-arylated secondary amines by using commercially available Zr(NMe2 )4 is reported. N-phenyl- and N-isopropylbenzylamine are used as amine substrates to establish the alkene substrate scope. Exclusively linear products are obtained in the presence of bulky vinylsilanes. Challenging α-heteroarylated amines and functionalized alkene substrates are compatible with this easy to use catalyst, affording a new disconnection strategy for the atom- and step-economic preparation of selectively substituted saturated α-arylated heterocycles. |
| Databáze: | OpenAIRE |
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