Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers
| Autor: | Rozemarie Gilles, Laurence G. Howes, Noreen M Vingerhoedt, Jan B Howes, Matthew Griffin |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Medicine (General) medicine.medical_specialty Cardiac index Hemodynamics Angiotensin-Converting Enzyme Inhibitors Blood Pressure 030204 cardiovascular system & hematology Benzoates Drug Administration Schedule 03 medical and health sciences R5-920 0302 clinical medicine Endocrinology Double-Blind Method Heart Rate Reference Values Internal medicine Internal Medicine medicine Humans Telmisartan Cardiac Output Pulse Cross-Over Studies Pulse (signal processing) business.industry Angiotensin II Crossover study Blood pressure medicine.anatomical_structure Injections Intravenous Vascular resistance Cardiology Benzimidazoles Female Vascular Resistance business medicine.drug |
| Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 4 (2003) |
| ISSN: | 1752-8976 1470-3203 |
| Popis: | Introduction This study investigated the central haemodynamic, blood pressure (BP) and pulse wave responses to progressively increasing infusion rates of intravenous angiotensin II (Ang II) in normal volunteers during chronic therapy with telmisartan or placebo. Materials and methods Ten normal volunteers, aged 21—33 years, completed a ramdomised, double-blind crossover study. Ang II was infused intravenously at increasing infusion rates (0—512 ng/minute) at the end of one week of telmisartan therapy (40—80 mg/day) and one week of placebo therapy. BP, central haemodynamics and pulse wave parameters were monitored continuous using a CardioDynamics Recorder, a Pulse Tracer Recorder and a Finipress Recorder. Results Baseline diastolic BP (5712 v G s. 67±13 mmHg) and pulse wave reflection ndex (RI) (38.4±18.6 vs. 60.6±12.5%) were significantly lower U on telmisartan than on placebo therapy. Cardiac index (CI), systolic BP, systemic vascular resistance index (SVRI), RI and pulse wave stiffness index (SI) were all significantly increased in a dose-dependent manner by Ang II on placebo therapy. Telmisartan significantly (p Conclusions Telmisartan effectively blocked the effects of intravenous Ang II on CI, BP, RI and SI in healthy volunteers. Changes in CI make a major contribution to increase in BP response to intravenous Ang II in normal volunteers. |
| Databáze: | OpenAIRE |
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