Comparison of the efficacy and safety of hybrid and sequential therapies as a first-line regimen for Helicobacter pylori infection in Turkey
| Autor: | Sebahat Basyigit, Serdar Ozkan, Yasar Nazligul, Abdullah Özgür Yeniova, Ayşe Kefeli |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Helicobacter pylori infection Helicobacter pylori biology business.industry Rabeprazole sequential regimen General Medicine Amoxicillin biology.organism_classification Gastroenterology 03 medical and health sciences Regimen Metronidazole 0302 clinical medicine Antibiotic resistance 030220 oncology & carcinogenesis Clarithromycin Internal medicine hybrid regimen medicine 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Archives of Medical Science. 14:276-280 |
| ISSN: | 1734-1922 |
| Popis: | WOS:000433028600003 PubMed: 29593799 Introduction: Helicobacter pylori infection is a common infection worldwide. The most frequently recommended treatment for eradication of H. pylori remains triple therapy. In this study, we compared sequential and hybrid regimens for H. pylori eradication in a region of Turkey with high resistance to clarithromycin. Material and methods: Three hundred and forty H. pylori-positive patients were enrolled in the study. The subjects were randomly divided into two groups. The first group (170 patients) received rabeprazole (40 mg/b.i.d.) and amoxicillin (1000 mg/b.i.d.) for 2 weeks and metronidazole and clarithromycin (500 mg/b.i.d.) during the second week in the hybrid therapy group. The second group (170 patients) received rabeprazole (40 mg/b.i.d.) for 14 days, amoxicillin (1000 mg/b.i.d.) for the first 7 days, and metronidazole plus clarithromycin (each 500 mg/b.i.d.) during the next 7 days in the sequential therapy group. Results: In the per-protocol analysis, the eradication rate in the hybrid therapy group was 96.1% (147/153), and in the sequential therapy group it was 90.9% (140/154). There was no significant difference between the two groups (p = 0.06). Ninety-seven of those 340 patients reported minor adverse drug reactions. The percentages of patients with adverse reactions were 30.6% in the hybrid therapy group and 26.5% in the sequential therapy group (p = 0.74). Conclusions: Both therapies are highly effective for eradication of H. pylori, and could be recommended as a first-line therapy in regions with high antibiotic resistance. |
| Databáze: | OpenAIRE |
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