The Clinical Spectrum of Necrotizing Glomerulonephritis
| Autor: | Furlong Tj, Ibels Ls, Eckstein Rp |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Vasculitis medicine.medical_specialty Adolescent Anti-Glomerular Basement Membrane Disease Kidney Glomerulus Population Renal function Gastroenterology Necrosis Glomerulonephritis Pulmonary-renal syndrome Internal medicine medicine Humans Goodpasture syndrome Child education Aged education.field_of_study medicine.diagnostic_test business.industry Granulomatosis with Polyangiitis General Medicine Middle Aged medicine.disease Child Preschool Infective endocarditis Female Renal biopsy business |
| Zdroj: | Medicine. 66:192-201 |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/00005792-198705000-00003 |
| Popis: | Twenty patients with necrotizing glomerulonephritis were seen at a general teaching hospital over a 6-year period. These patients represented 5.2% of the histologically verified glomerulonephritis population. Twelve patients had an associated systemic illness (vasculitis in 6, Wegener's granulomatosis in 2, Goodpasture syndrome in 2, infective endocarditis in 1, pulmonary renal syndrome in 1). The clinical course was variable, with equal numbers of patients having rapidly progressive and indolent courses. Four patients (20%) had less than 10% normal glomeruli on renal biopsy and developed end-stage renal failure. Although immunosuppressive and anticoagulant therapy was associated with an improvement in renal function, 6 patients (30%) had died after a mean follow-up period of 25 months. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|