Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment
| Autor: | Ivan Sterzl, Zuzana Humlová, Karin Malickova, Vladimír Vonka, Zdeněk Roth, Eva Hamsikova, Ivana Janatková, Petra Kralikova, Hana Klamová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male lcsh:Immunologic diseases. Allergy Article Subject T-Lymphocytes Lymphocyte Immunology Population Dasatinib Immunoglobulins Alpha interferon Antineoplastic Agents Piperazines Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases medicine Humans Hydroxyurea Immunologic Factors Immunology and Allergy Longitudinal Studies Interleukin 6 education Protein Kinase Inhibitors education.field_of_study biology Interleukin-6 C-reactive protein Interferon-alpha Myeloid leukemia Complement System Proteins General Medicine Middle Aged Immunity Innate Thiazoles C-Reactive Protein Pyrimidines Treatment Outcome Imatinib mesylate medicine.anatomical_structure Benzamides Imatinib Mesylate biology.protein Female lcsh:RC581-607 Research Article medicine.drug |
| Zdroj: | Clinical and Developmental Immunology, Vol 2010 (2010) Clinical and Developmental Immunology |
| ISSN: | 1740-2530 1740-2522 |
| Popis: | In the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex. We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C-reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells. Eleven of these patients were followed longitudinally. After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them. There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment. |
| Databáze: | OpenAIRE |
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