Development of an Ointment Formulation Using Hot-Melt Extrusion Technology
| Autor: | Abhijeet Maurya, Roshan V. Tiwari, Muralikrishnan Angamuthu, Seyed Meysam Hashemnejad, Santanu Kundu, Hemlata Patil, Ajinkya M. Bhagurkar, S. Narasimha Murthy, Michael A. Repka |
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| Rok vydání: | 2015 |
| Předmět: |
Hot Temperature
Materials science Chemistry Pharmaceutical Drug Compounding Pharmaceutical Science 02 engineering and technology Polyethylene glycol Aquatic Science 030226 pharmacology & pharmacy Ointments 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheology Drug Discovery Texture (crystalline) Composite material Hot melt Ecology Evolution Behavior and Systematics Drug Carriers Fusion Ecology General Medicine 021001 nanoscience & nanotechnology Drug Liberation chemistry Base ointment Extrusion 0210 nano-technology Drug carrier Agronomy and Crop Science Research Article |
| Zdroj: | AAPS PharmSciTech. 17:158-166 |
| ISSN: | 1530-9932 |
| DOI: | 10.1208/s12249-015-0453-3 |
| Popis: | Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids. |
| Databáze: | OpenAIRE |
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