Hematopoietic Stem Cell Regulation by the Proteostasis Network
| Autor: | Bernadette A. Chua, Robert A.J. Signer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell physiology Aging Proteome Immunology Clinical Sciences Biology Cardiorespiratory Medicine and Haematology Article 03 medical and health sciences 0302 clinical medicine medicine Humans Healthy aging Progenitor cell Hematopoietic stem cell Hematology Hematopoietic Stem Cells Cell biology Haematopoiesis 030104 developmental biology medicine.anatomical_structure Proteostasis Stem cell Homeostasis 030215 immunology |
| Zdroj: | Curr Opin Hematol Current opinion in hematology, vol 27, iss 4 |
| Popis: | PURPOSE OF REVIEW: Protein homeostasis (proteostasis) is maintained by an integrated network of physiological mechanisms and stress response pathways that regulate the content and quality of the proteome. The maintenance of cellular proteostasis is key to ensuring normal development, resistance to environmental stress, coping with infection, and promoting healthy aging and lifespan. However, recent studies have revealed that several proteostasis mechanisms can function in a cell-type specific manner, including within hematopoietic stem cells (HSCs). Here, we review recent studies demonstrating that the proteostasis network functions uniquely in HSCs to promote their maintenance and regenerative function. RECENT FINDINGS: Despite being highly-conserved cellular processes, several components of the proteostasis network, including protein synthesis, protein degradation, and the unfolded protein response, are regulated differently in HSCs as compared to restricted hematopoietic progenitors. Disruption of these proteostasis mechanisms are particularly detrimental to HSC maintenance and function. Together, these findings suggest that these aspects of cellular physiology are uniquely regulated in HSCs to maintain proteostasis, and that precise control of proteostasis is particularly important to support life-long HSC maintenance and regenerative function. SUMMARY: Emerging data suggest that the proteostasis network is uniquely configured within HSCs to promote their longevity and hematopoietic function. Future work uncovering cell-type specific differences in proteostasis network configuration, integration, and function will be essential for understanding how HSCs function during homeostasis, in response to stress, and in disease. |
| Databáze: | OpenAIRE |
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