Reduction of cortisol levels after single intra-articular and intramuscular steroid injection
| Autor: | Ivan Zgradic, Barry L. Myones, William I. Swedler, Gordana Djordjevic-Denic, John L. Skosey, Milenko B. Lazarevic |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypothalamo-Hypophyseal System Hydrocortisone medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Pituitary-Adrenal System Injections Intramuscular Methylprednisolone Injections Intra-Articular Internal medicine medicine Humans Aged Diminution business.industry General Medicine Methylprednisolone acetate Middle Aged Methylprednisolone Acetate Steroid hormone Endocrinology Corticosteroid Female Steroids Intramuscular injection business Glucocorticoid medicine.drug |
| Zdroj: | The American journal of medicine. 99(4) |
| ISSN: | 0002-9343 |
| Popis: | BACKGROUND : This study was undertaken to determine the influence of single intra-articular or intra muscular injections of methylprednisolone acetate on the hypothalamic-pituitary-adrenal axis. PATIENTS AND METHODS : Twenty-one patients with rheumatic disease who had never been treated with systemic glucocorticoids and had not received local injections of these agents for the preceding 2 months, were given 40 mg of methylprednisolone acetate. Group I (11 patients) received one intra-articular injection into the knee, and Group II (10 patients) received the same dose intramuscularly. RESULTS : In Group I, serum cortisol levels were significantly decreased 24 hours after injection (228.2 ± 8.7 nmol/L versus 193 ± 16.3 nmol/L ; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|