Medial temporal lobe cortical changes in response to exercise interventions in people with early psychosis: A randomized controlled trial
| Autor: | Melissa L. Woodward, Donna J. Lang, Wayne Su, Jingxia Lin, Kristina M. Gicas, Eric Y.H. Chen, Christy L.M. Hui, William G. Honer |
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| Rok vydání: | 2020 |
| Předmět: |
Psychosis
medicine.medical_specialty Temporal lobe law.invention 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Randomized controlled trial law Hatha yoga Neuroplasticity Humans Medicine Aerobic exercise Exercise Biological Psychiatry Temporal cortex business.industry medicine.disease Temporal Lobe Exercise Therapy 030227 psychiatry Psychiatry and Mental health Psychotic Disorders Cohort Hong Kong Female business 030217 neurology & neurosurgery |
| Zdroj: | Schizophrenia Research. 223:87-95 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2020.05.043 |
| Popis: | Objective Individuals with early psychosis may have prefrontal-limbic cortical deficits, which are associated with symptom severity and cognitive impairment. This study investigated the impact of an exercise intervention on fronto-temporal cortical plasticity in female participants with early psychosis. Methods In a cohort of 51 female participants with early psychosis from Hong Kong, we investigated the effects of a 12-week, moderate intensity aerobic or Hatha yoga exercise trial (yoga (N = 21), aerobic (N = 18) or waitlist group (N = 12)) on cortical grey matter. Clinical assessments and structural MRI were completed pre- and post- a 12-week exercise intervention. Results Increases in cortical volume and thickness were observed in the medial temporal cortical regions, primarily in fusiform cortical thickness (F(2, 48) = 4.221, p = 0.020, η2 = 0.150) and volume (F(2, 48) = 3.521, p = 0.037, η2 = 0.128) for participants with early psychosis in the aerobic arm, but not in the yoga and waitlist arms. Increased fusiform cortical thickness (s = 0.402, p = 0.003) was associated with increased hippocampal volume for all psychosis participants. For the aerobic group only, increases in the entorhinal and fusiform temporal gyri were associated with reduced symptom severity. Conclusions These findings suggest exercise-induced neuroplasticity in medial temporal cortical regions occurs with aerobic exercise. These changes may be associated with improvements in psychosis symptom severity. People with early psychosis may benefit from exercise interventions, particularly aerobic exercise, as an adjunct treatment to address clinical, physical health, and neuroanatomic concerns. NIH National Library of Medicine ClinicalTrials.gov Registration #: NCT01207219 https://clinicaltrials.gov/ct2/show/NCT01207219 |
| Databáze: | OpenAIRE |
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