Optimisation and quality control of cell processing for autologous stem cell transplantation
| Autor: | Michael J. Watts, David C. Linch |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Quality Control
medicine.medical_specialty Cell processing media_common.quotation_subject Cell CD34 030204 cardiovascular system & hematology Biology Transplantation Autologous Cryopreservation 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation medicine Humans Quality (business) Progenitor cell Intensive care medicine media_common Graft Survival Hematopoietic Stem Cell Transplantation Hematology Hematopoietic Stem Cells Haematopoiesis medicine.anatomical_structure Immunology 030215 immunology |
| Zdroj: | British Journal of Haematology. 175:771-783 |
| ISSN: | 0007-1048 |
| Popis: | Clinical practice and the technology of cell processing for autologous stem cell transplantation has continued to evolve over the last two decades and merits review of current quality control expectations. The external regulatory era has improved quality and safety standards but there is still variable practice, with specific risks illuminated by a number of clinical incidents. Viable CD34+ cell assays may fail to indicate significant losses in progenitor function during storage, particularly after cryopreservation, and there is a need to develop an alternative, real time functional assay to replace colony assays. The ultimate guide to potency and successful cell processing for haematopoietic progenitor cell products is prompt and reproducible engraftment and close monitoring is essential for safety and quality control. |
| Databáze: | OpenAIRE |
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