Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Autor: B.W.J.H. Penninx, Henry Völzke, Wiro J. Niessen, Nicholas G. Martin, Bernhard T. Baune, D. Schoepf, Michael Czisch, Neda Jahanshad, Jeremy Hall, Walter Heindel, Knut Schnell, Carsten Konrad, Nikolay A. Bokhan, Miguel E. Rentería, Lyubomir I. Aftanas, Christopher G. Davey, Martin Walter, Sean N. Hatton, M. A. Ikram, Joshua W. Cheung, Baptiste Couvy-Duchesne, M Selonke, Dick J. Veltman, Meng Li, Paul M. Thompson, M-J van Tol, Katharina Wittfeld, Thomas Frodl, L. S. van Velzen, Ben J. Harrison, Matthew D. Sacchet, Bartosz Zurowski, D. Hoehn, Ilya M. Veer, Nils Opel, Beata R. Godlewska, Meike W. Vernooij, Eva-Maria Frey, Henning Tiemeier, Oliver Gruber, Bernd Krämer, Angela Carballedo, Derrek P. Hibar, G.I. de Zubicaray, Ian H. Gotlib, Lianne Schmaal, Dominik Grotegerd, Thomas Nickson, Andrew M. McIntosh, Roberto Goya-Maldonado, Jim Lagopoulos, Philipp G. Sämann, Deborah Janowitz, J.E. Sussmann, Heather C. Whalley, Geoffrey B. Hall, Ivan Brack, Elisabeth Schramm, T.G.M. van Erp, Henrik Walter, Volker Arolt, Daniel Bos, Robin Bülow, Katie L. McMahon, Claus Normann, Sarah E. Medland, Lachlan T. Strike, Glenda MacQueen, Hans-Jörgen Grabe, Nathan A. Gillespie, Benson Mwangi, Bo Cao, Udo Dannlowski, Harald Kugel, Jair C. Soares, Natalie T. Mills, N.J. van der Wee, Margaret J. Wright, Ian B. Hickie, Martina Papmeyer, A. Hofman
Přispěvatelé: Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Anatomy and neurosciences, APH - Digital Health, Epidemiology, Radiology & Nuclear Medicine, Neurology, Medical Informatics, Child and Adolescent Psychiatry / Psychology
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
pathology [Frontal Lobe]
Audiology
methods [Magnetic Resonance Imaging]
0302 clinical medicine
взрослые
pathology [Brain]
pathology [Gray Matter]
diagnostic imaging [Cerebral Cortex]
Gray Matter
LIFE-SPAN
Cerebral Cortex
First episode
pathology [Depressive Disorder
Major]
Brain
Magnetic Resonance Imaging
Temporal Lobe
Frontal Lobe
3. Good health
Psychiatry and Mental health
medicine.anatomical_structure
Frontal lobe
VOXEL-BASED MORPHOMETRY
pathology [Gyrus Cinguli]
Major depressive disorder
Female
Original Article
DRUG-NAIVE
methods [Neuroimaging]
Psychology
psychology [Neuroimaging]
Adult
medicine.medical_specialty
MOOD DISORDERS
магнитно-резонансная томография головного мозга
Adolescent
Prefrontal Cortex
Neuroimaging
610 Medicine & health
SURFACE-AREA
diagnostic imaging [Depressive Disorder
Major]
Gyrus Cinguli
behavioral disciplines and activities
03 medical and health sciences
Cellular and Molecular Neuroscience
THICKNESS
mental disorders
medicine
Humans
ddc:610
Molecular Biology
Anterior cingulate cortex
GRAY-MATTER VOLUME
METAANALYSIS
корковые аномалии
Depressive Disorder
Major
pathology [Temporal Lobe]
Voxel-based morphometry
HEALTHY-CHILDREN
medicine.disease
R1
pathology [Prefrontal Cortex]
030227 psychiatry
депрессивные расстройства
Superior frontal gyrus
ANTERIOR CINGULATE CORTEX
Posterior cingulate
pathology [Cerebral Cortex]
Orbitofrontal cortex
Neuroscience
подростки
030217 neurology & neurosurgery
Zdroj: Molecular psychiatry. 2017. Vol. 22, № 6. P. 900-909
Molecular Psychiatry, 22(6), 900-909. Nature Publishing Group
Schmaal, L, Hibar, D P, Sämann, P G, Hall, G B, Baune, B T, Jahanshad, N, Cheung, J W, Van Erp, T G M, Bos, D, Ikram, M A, Vernooij, M W, Niessen, W J, Tiemeier, H, Hofman, A, Wittfeld, K, Grabe, H J, Janowitz, D, Bülow, R, Selonke, M, Völzke, H, Grotegerd, D, Dannlowski, U, Arolt, V, Opel, N, Heindel, W, Kugel, H, Hoehn, D, Czisch, M, Couvy-duchesne, B, Rentería, M E, Strike, L T, Wright, M J, Mills, N T, De Zubicaray, G I, Mcmahon, K L, Medland, S E, Martin, N G, Gillespie, N A, Goya-maldonado, R, Gruber, O, Krämer, B, Hatton, S N, Lagopoulos, J, Hickie, I B, Frodl, T, Carballedo, A, Frey, E M, Van Velzen, L S, Penninx, B W J H, Van Tol, M, Van Der Wee, N J, Davey, C G, Harrison, B J, Mwangi, B, Cao, B, Soares, J C, Veer, I M, Walter, H, Schoepf, D, Zurowski, B, Konrad, C, Schramm, E, Normann, C, Schnell, K, Sacchet, M D, Gotlib, I H, Macqueen, G M, Godlewska, B R, Nickson, T, Mcintosh, A M, Papmeyer, M, Whalley, H C, Hall, J, Sussmann, J E, Li, M, Walter, M, Aftanas, L, Brack, I, Bokhan, N A, Thompson, P M & Veltman, D J 2016, ' Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group ', Molecular Psychiatry . https://doi.org/10.1038/mp.2016.60
Schmaal, L; Hibar, D P; Sämann, P G; Hall, G B; Baune, B T; Jahanshad, N; Cheung, J W; van Erp, T G M; Bos, D; Ikram, M A; Vernooij, M W; Niessen, W J; Tiemeier, H; Hofman, A; Wittfeld, K; Grabe, H J; Janowitz, D; Bülow, R; Selonke, M; Völzke, H; ... (2017). Cortical Abnormalities in Adults and Adolescents with Major Depression based on Brain Scans from 20 Cohorts Worldwide in the ENIGMA Major Depressive Disorder Working Group. Molecular psychiatry, 22(6), pp. 900-909. Nature Publishing Group 10.1038/mp.2016.60
Molecular Psychiatry, 22(6), 900-909
Schmaal, L; Hibar, DP; Saemann, PG; Hall, GB; Baune, BT; Jahanshad, N; et al.(2017). Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. MOLECULAR PSYCHIATRY, 22(6), 900-909. doi: 10.1038/mp.2016.60. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9f0214xz
Molecular Psychiatry
Schmaal, L, Hibar, D P, Sämann, P G, Hall, G B, Baune, B T, Jahanshad, N, Cheung, J W, Van Erp, T G M, Bos, D, Ikram, M A, Vernooij, M W, Niessen, W J, Tiemeier, H, Hofman, A, Wittfeld, K, Grabe, H J, Janowitz, D, Bülow, R, Selonke, M, Völzke, H, Grotegerd, D, Dannlowski, U, Arolt, V, Opel, N, Heindel, W, Kugel, H, Hoehn, D, Czisch, M, Couvy-Duchesne, B, Rentería, M E, Strike, L T, Wright, M J, Mills, N T, De Zubicaray, G I, McMahon, K L, Medland, S E, Martin, N G, Gillespie, N A, Goya-Maldonado, R, Gruber, O, Krämer, B, Hatton, S N, Lagopoulos, J, Hickie, I B, Frodl, T, Carballedo, A, Frey, E M, Van Velzen, L S, Penninx, B W J H, Van Tol, M J, Van der Wee, N J, Davey, C G, Harrison, B J, Mwangi, B, Cao, B, Soares, J C, Veer, I M, Walter, H, Schoepf, D, Zurowski, B, Konrad, C, Schramm, E, Normann, C, Schnell, K, Sacchet, M D, Gotlib, I H, MacQueen, G M, Godlewska, B R, Nickson, T, McIntosh, A M, Papmeyer, M, Whalley, H C, Hall, J, Sussmann, J E, Li, M, Walter, M, Aftanas, L, Brack, I, Bokhan, N A, Thompson, P M & Veltman, D J 2017, ' Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group ', Molecular Psychiatry, vol. 22, no. 6, pp. 900-909 . https://doi.org/10.1038/mp.2016.60
MOLECULAR PSYCHIATRY
Molecular psychiatry 22(6), 900-909 (2016). doi:10.1038/mp.2016.60
ISSN: 1359-4184
Popis: The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.
Databáze: OpenAIRE
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