An LC-MS/MS method for creatine and creatinine analysis in paraquat-intoxicated patients
| Autor: | Mukdawan Sukhang, Anongphan Junkuy, Fahim Mohamed, Nicholas A. Buckley, Klintean Wunnapuk |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Paraquat
Spectrometry Mass Electrospray Ionization Renal function macromolecular substances Pharmacology Creatine 01 natural sciences Nephrotoxicity Cohort Studies 03 medical and health sciences chemistry.chemical_compound Limit of Detection Tandem Mass Spectrometry Liquid chromatography–mass spectrometry Lc ms ms Humans Medicine skin and connective tissue diseases 030304 developmental biology 0303 health sciences Creatinine business.industry 010401 analytical chemistry Acute kidney injury Reproducibility of Results General Medicine medicine.disease Pollution 0104 chemical sciences chemistry Calibration sense organs business Chromatography Liquid Food Science |
| Zdroj: | Journal of Environmental Science and Health, Part B. 55:273-282 |
| ISSN: | 1532-4109 0360-1234 |
| Popis: | A sudden increase in serum creatinine after paraquat intoxication has been reported in several clinical studies. However, this dramatic change of creatinine may be possibly due to an interconversion of creatine-creatinine in relation to paraquat toxicity. In order to investigate the creatine-creatinine relationship, a liquid chromatography tandem mass spectrometry in combination with electrospray ionization was developed and validated for simultaneous determination of creatine and creatinine in the serum. The chromatographic separation was achieved on a Gemini® C |
| Databáze: | OpenAIRE |
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