Usefulness of serial measurement of N-terminal pro-brain natriuretic peptide plasma levels in asymptomatic patients with aortic stenosis to predict symptomatic deterioration
| Autor: | Ralph A.H. Stewart, Malcolm E. Legget, A. Mark Richards, Ivor L. Gerber, Teena West |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Hemodynamics Nerve Tissue Proteins Asymptomatic Valve replacement Predictive Value of Tests Internal medicine Natriuretic Peptide Brain Natriuretic peptide medicine Humans Aged Aged 80 and over Ejection fraction business.industry Aortic Valve Stenosis Plasma levels Middle Aged medicine.disease Peptide Fragments Stenosis Predictive value of tests Disease Progression cardiovascular system Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | The American Journal of Cardiology. 95:898-901 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2004.11.053 |
| Popis: | In 29 initially asymptomatic patients with aortic stenosis followed for an average of 18 months, patients with a N-terminal pro-brain natriuretic peptide (NT-pro-BNP) level above the normal range at baseline were more likely to develop symptoms during follow-up compared with patients with NT-pro-BNP within normal limits. The average increase in NT-pro-BNP per year was greater for patients who developed symptoms compared with patients who remained asymptomatic. Aortic valve area, peak aortic velocity, and the ejection fraction were less reliable predictors of symptom onset. Measurement of NT-pro-BNP in addition to clinical assessment and echocardiography may allow more reliable follow-up and timing of valve replacement for aortic stenosis. |
| Databáze: | OpenAIRE |
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