NPM1, FLT3, and c-KIT Mutations in Pediatric Acute Myeloid Leukemia in Russian Population
| Autor: | Olga Kalennik, Irina Kalinina, Mikhail Maschan, Tatyana V. Nasedkina, Yuliya Yatsenko, Alexey Maschan |
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| Rok vydání: | 2013 |
| Předmět: |
Male
NPM1 Adolescent Russia chemistry.chemical_compound hemic and lymphatic diseases medicine Humans Child Chromosome Aberrations business.industry Pediatric acute myeloid leukemia Childhood Acute Myeloid Leukemia Infant Newborn Infant Nuclear Proteins RNA Hematology Prognosis Survival Rate Leukemia Myeloid Acute Proto-Oncogene Proteins c-kit medicine.anatomical_structure fms-Like Tyrosine Kinase 3 Oncology chemistry Child Preschool Mutation Pediatrics Perinatology and Child Health Immunology Russian population Female Bone marrow business Nucleophosmin DNA |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 35:e100-e108 |
| ISSN: | 1077-4114 |
| Popis: | We evaluated frequencies of NPM1, FLT3, c-KIT mutations in childhood acute myeloid leukemia (AML) in Russia and assessed prognostic relevance of the mutations. RNA and DNA were extracted from bone marrow samples of 186 (106 male and 80 female) pediatric patients younger than 17 year with de novo AML. Mutations and chromosomal rearrangements were detected by sequencing of a corresponding gene. NPM1 mutations were found in 5.2%, FLT3 mutations in 12.1%, c-KIT mutations in 3.7% of the patients. NPM1 mutations were associated with the absence of chromosomal aberrations (P=0.007) and FLT3/ITD (P=0.018). New data on incidence of c-KIT mutations in various AML subtypes as well as new variations of c-KIT mutations in the exon 8 are presented. The results are compared to previously published studies on NPM1, FLT3, c-KIT mutations in various populations. No statistically significant differences in survival rates between groups with or without of FLT3, NPM1, c-KIT mutations were found (P0.05). Meanwhile, 4-year overall survival rates were higher in patients having NPM1 mutations comparing with NPM1/WT patients (100% vs. 50%) and in patients having FLT3 mutations comparing with FLT3/WT patients (70% vs. 50%). The data presented contribute to knowledge on incidence and prognostic significance of the mutations in pediatric AML. |
| Databáze: | OpenAIRE |
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