Using proximity extension proteomics assay to discover novel biomarkers associated with circulating leptin levels in patients with type 2 diabetes
| Autor: | Tobias Feldreich, Johan Sundström, Lars Lind, Camilla Vavruch, Fredrik H. Nystrom, Stefan Söderberg, Johan Ärnlöv, Carl Johan Östgren, Christoph Nowak |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
False discovery rate Leptin Male Proteomics medicine.medical_specialty lcsh:Medicine Disease Type 2 diabetes Endocrinology and Diabetes Predictive markers Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Cardiac and Cardiovascular Systems lcsh:Science Aged Multidisciplinary Kardiologi business.industry Incidence (epidemiology) lcsh:R Diabetes Middle Aged medicine.disease Blood proteins 030104 developmental biology Endocrinology Cardiovascular diseases Diabetes Mellitus Type 2 Cohort Endokrinologi och diabetes lcsh:Q Female business 030217 neurology & neurosurgery Mace Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| Popis: | We aimed to discover novel associations between leptin and circulating proteins which could link leptin to the development of cardiovascular disease in patients with type 2 diabetes (T2DM). In a discovery phase, we investigated associations between 88 plasma proteins, assessed with a proximity extension assay, and plasma leptin in a cohort of middle-aged patients with T2DM. Associations passing the significance threshold of a False discovery rate of 5% (corresponding to pFunding Agencies|FORSS, the Research Council of Southeastern Sweden; Swedish Heart-Lung foundationSwedish Heart-Lung Foundation; King Gustaf V and Queen Victoria Freemason Foundation, Sweden; Linkoping University; Uppsala University Hospital |
| Databáze: | OpenAIRE |
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