B(12)-mediated, long wavelength photopolymerization of hydrogels
| Autor: | Malcolm D. E. Forbes, David S. Lawrence, Laura M. Doherty, Jennifer R. Shell, Alexander M. Brugh, Andrew M. Moran, Brian P. Molesky, Robert M. Hughes, Zachary L. Rodgers |
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| Rok vydání: | 2015 |
| Předmět: |
Light
Cell Survival Photochemistry Nanotechnology Biochemistry Catalysis Article Polyethylene Glycols Polymerization chemistry.chemical_compound Propane Colloid and Surface Chemistry Polymer chemistry Materials Testing Humans Curing (chemistry) Transdermal Skin Melanins Photolysis Hydrogels General Chemistry Hep G2 Cells Long wavelength Wavelength Vitamin B 12 Monomer Photopolymer chemistry Acrylates Self-healing hydrogels |
| Zdroj: | Journal of the American Chemical Society. 137(9) |
| ISSN: | 1520-5126 |
| Popis: | Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600–900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. Photoactivation occurs within a range of skin type models containing high biochromophore concentrations. |
| Databáze: | OpenAIRE |
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