Electrical Tongue Stimulation Normalizes Activity Within the Motion-Sensitive Brain Network in Balance-Impaired Subjects as Revealed by Group Independent Component Analysis
| Autor: | Yuri Danilov, Kurt A. Kaczmarek, Mitchell E. Tyler, Mary E. Meyerand, Joseph C. Wildenberg |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Visual perception genetic structures Motion Perception Stimulation Tongue Neuroplasticity medicine Humans Gait Postural Balance Balance (ability) Principal Component Analysis medicine.diagnostic_test General Neuroscience Brain Original Articles Middle Aged Magnetic Resonance Imaging Electric Stimulation Visual field Visual cortex medicine.anatomical_structure Female Nerve Net Functional magnetic resonance imaging Psychology Neuroscience Photic Stimulation Psychomotor Performance |
| Zdroj: | Brain Connectivity. 1:255-265 |
| ISSN: | 2158-0022 2158-0014 |
| Popis: | Multivariate analysis of functional magnetic resonance imaging (fMRI) data allows investigations into network behavior beyond simple activations of individual regions. We apply group independent component analysis to fMRI data collected in a previous study looking at the sustained neuromodulatory effects of electrical tongue stimulation in balance-impaired individuals. Twelve subjects with balance disorders viewed optic flow in an fMRI scanner before and after 5 days of electrical tongue stimulation. Nine healthy controls also viewed the visual stimuli but did not receive any stimulation. Multiple regression of the 47 estimated components found two that were modulated by the visual stimuli. Component 7, comprised primarily of the primary visual cortex (V1), responded to all visual stimuli and showed no difference in task-related activity between the healthy controls and the balance-impaired subjects before or after stimulation. Component 11 responded only to motion in the visual field and contained multiple cortical and subcortical regions involved in processing information pertinent to balance. Two-sample t-tests of the calculated signal change revealed that the task-related activity of this network is greater in balance-impaired subjects compared with controls before stimulation (p=0.02), but that this network hypersensitivity decreases after electrical tongue stimulation (p=0.001). |
| Databáze: | OpenAIRE |
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