The potential role of hepatitis C virus in the pathogenesis of the neurological syndrome in chronic hepatitis C
| Autor: | Giancarlo Guazzi, Pier Egisto Valensin, I. Bastianoni, M. G. Padula, P. Almi, D. Maimone, C. Caudai, C. A. Boggiano, Pasquale Annunziata |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Hepatitis C virus Hepacivirus Case Report Antibodies Viral medicine.disease_cause Polymerase Chain Reaction Virus Immunoenzyme Techniques Pathogenesis medicine Humans Neurons Afferent Aged Hepatitis Chronic Hepatitis biology business.industry Gastroenterology virus diseases Hepatitis C medicine.disease biology.organism_classification digestive system diseases Peripheral neuropathy Immunology RNA Viral Viral disease Nervous System Diseases business |
| Zdroj: | Gut. 41:411-412 |
| ISSN: | 1468-3288 0017-5749 |
| DOI: | 10.1136/gut.41.3.411 |
| Popis: | A 72 year old man developed chronic sensory neuropathy (CSN) during chronic hepatitis C (HCV) infection. Neurological symptoms began one year after acute HCV hepatitis and slowly worsened over three years. No conventional cause for CSN was found. Circulating antinervous tissue antibodies (including anti-Hu) and inflammatory infiltrates in sural nerve biopsy specimens were absent. However, the presence of anti-HCV antibody and HCV-RNA in cerebrospinal fluid indicated that HCV had reached the intrathecal compartment, suggesting the direct viral involvement in the pathogenesis of CSN. |
| Databáze: | OpenAIRE |
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