Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties
Autor: | Elżbieta Ławrecka, Katarzyna Centkowska, Małgorzata Sznitowska |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Drug
Materials science media_common.quotation_subject Pharmaceutical Science lcsh:RS1-441 02 engineering and technology Loratadine mechanical properties 030226 pharmacology & pharmacy Polyvinyl alcohol Article lcsh:Pharmacy and materia medica 03 medical and health sciences Viscosity chemistry.chemical_compound 0302 clinical medicine medicine suspension Composite material media_common chemistry.chemical_classification Tear resistance Aqueous solution Polymer 021001 nanoscience & nanotechnology HPMC matrix content uniformity chemistry viscosity orodispersible film loratadine 0210 nano-technology medicine.drug |
Zdroj: | Pharmaceutics, Vol 12, Iss 3, p 250 (2020) Pharmaceutics Volume 12 Issue 3 |
ISSN: | 1999-4923 |
Popis: | The production of orodispersible films (ODFs) with suspended insoluble drug substances is still a challenge, mainly due to the difficulty associated with achieving a proper homogeneity and mechanical properties of the films. Hypromellose (HPMC) and a mixture of polyvinyl alcohol (AP) and povidone (PVP) were compared in terms of their suitability for ODFs incorporating suspended micronized loratadine (LO) in a concentration range of 10%&ndash 40%. In a planetary mixer (Thinky), a uniform dispersion of LO in an aqueous viscous casting solution was obtained. The suspended LO particles caused dose-dependent changes in the viscosity of the casting mass and affected the mechanical quality of ODFs. Drug concentrations higher than 30% reduced the film flexibility and tear resistance, depending on the polymer type. LO films with a thickness of 100 µ m disintegrated within 60-100 s, with no significant influence of the LO content in the range 10%&ndash 30%. HPMC films, regardless of the drug concentration, met the pharmacopoeial requirements regarding the uniformity of the drug content. AP/PVP films were too elastic, and the drug content uniformity was not achieved. The conclusion is that, using an HPMC matrix, it is possible to obtain a high load of a poorly water-soluble drug (30% of dry film mass corresponds to a dose of 5 mg per 1.5 cm2) in ODFs characterized by proper physical characteristics. |
Databáze: | OpenAIRE |
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