Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis
| Autor: | Marta E. Alarcón-Riquelme, Alejandra Babini, Ingrid Strusberg, Marco A. Maradiaga-Ceceña, César Graf, Osvaldo D. Messina, Teresa Tusié-Luna, José Luis C. Moreno, Sergio Paira, Elena Sánchez, Mario Goñi, Jorge A. Esquivel-Valerio, Eduardo Acevedo-Vásquez, Ignacio García-De La Torre, Luis J. Catoggio, Genar Study, Guillermo A. Berbotto, Gustavo Citera, Bernardo A. Pons-Estel, Conrado García García, Alberto Spindler, Alejandro Alvarellos, Jorge L. Musuruana, Francisco J. Ballesteros, Antonio Catalán Pellet, Sergio Toloza, G Nasswetter, Ana Quinteros, Guillermo Tate, Alicia Eimon, Juan Carlos Marcos, Mario H. Cardiel, Hugo R. Scherbarth, Mónica P. Sacnun, Pedro C. Miranda |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Latin Americans Arthritis Rheumatoid 0302 clinical medicine Genotype Peru Immunology and Allergy AMERINDIAN Chile Traditional medicine Anti-Inflammatory Agents Non-Steroidal Age Factors Middle Aged ADMIXTURE Rheumatoid arthritis Antirheumatic Agents Female SMOKING Leflunomide medicine.drug Adult medicine.medical_specialty Genetic genealogy Immunology Argentina LATIN AMERICAN 03 medical and health sciences Sex Factors Rheumatology Sulfasalazine Rheumatoid Factor Internal medicine medicine Rheumatoid factor Humans In patient Allele RHEUMATOID ARTHRITIS Mexico Alleles Aged 030203 arthritis & rheumatology business.industry Indians South American Isoxazoles medicine.disease Radiography 030104 developmental biology Methotrexate Indians North American business |
| Zdroj: | The Journal of rheumatology. 44(12) |
| ISSN: | 0315-162X |
| Popis: | Objective.To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America.Methods.Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history.Results.Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p < 0.0001, OR 0.05), rheumatoid factor (RF; p < 0.0001, OR 0.22), radiographic changes (p < 0.0001, OR 0.05), and higher number of criteria were associated with lower Amerindian ancestry after Bonferroni correction. Higher Amerindian ancestry correlated only with weight loss (pBonferroni < 0.0001, OR 2.85). Increased Amerindian ancestry correlated with higher doses of azathioprine (p < 0.0001, OR 163.6) and sulfasalazine (p < 0.0001, OR 48.6), and inversely with methotrexate (p = 0.001, OR 0.35), leflunomide (p = 0.001, OR 0.16), and nonsteroidal antiinflammatory drugs (pBonferroni = 0.001, OR 0.37). Only the presence of RF and weight loss were modified after confounders adjustment.Conclusion.Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|