AIP56: A Novel Bacterial Apoptogenic Toxin
| Autor: | Nuno M.S. dos Santos, Manuel T. Silva, Ana do Vale |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Neutrophils
Virulence Factors AIP56 Health Toxicology and Mutagenesis Bacterial Toxins lcsh:Medicine Review Biology Toxicology medicine.disease_cause Virulence factor Microbiology 03 medical and health sciences Photobacterium damselae subsp. piscicida secondary necrosis In vivo AB toxin medicine Animals Humans Pathogen 030304 developmental biology chemistry.chemical_classification 0303 health sciences 030306 microbiology Photobacterium Macrophages lcsh:R apoptosis 3. Good health Amino acid Photobacterium damselae chemistry Neutrophil elastase biology.protein Exotoxin |
| Zdroj: | Toxins, Vol 2, Iss 4, Pp 905-918 (2010) Toxins |
| ISSN: | 2072-6651 |
| Popis: | Photobacterium damselae subsp. piscicida (Phdp) is a Gram-negative pathogen agent of an important fish septicemia. The key virulence factor of Phdp is the plasmid-encoded exotoxin AIP56, which is secreted by exponentially growing pathogenic strains. AIP56 has 520 amino acids including an N-terminal cleavable signal peptide of 23 amino acid residues, two cysteine residues and a zinc-binding region signature HEXXH that is typical of most zinc metallopeptidases. AIP56 induces in vitro and in vivo selective apoptosis of fish macrophages and neutrophils through a caspase-3 dependent mechanism that also involves caspase-8 and -9. In vivo, the AIP56-induced phagocyte apoptosis progresses to secondary necrosis with release of cytotoxic phagocyte molecules including neutrophil elastase. Fish injected with recombinant AIP56 die with a pathology similar to that seen in the natural infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|