Risk Factors and Correlates of Neonatal Growth Velocity in Extremely Low Gestational Age Newborns. The ELGAN Study
| Autor: | Julie Bartholomew, Alan Leviton, Minghua L. Chen, Camilia R. Martin, Elizabeth N. Allred, Richard A. Ehrenkranz, Olaf Dammann |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Multivariate analysis Gestational Age Article Growth velocity Risk Factors medicine Humans Growth Disorders Retrospective Studies Extremely premature business.industry Extramural Obstetrics Infant Newborn Gestational age Retrospective cohort study Infant Low Birth Weight Infant newborn Low birth weight Infant Extremely Premature Multivariate Analysis Pediatrics Perinatology and Child Health Female medicine.symptom Energy Intake business Developmental Biology |
| Zdroj: | Neonatology. 104:298-304 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000351020 |
| Popis: | Objectives: To identify maternal and infant characteristics associated with reduced growth velocity (GV) in extremely premature newborns. Methods: We evaluated 1,187 infants born between 23 and 27 weeks' gestation at 14 institutions between 2002 and 2004 who survived until day 28 to identify the maternal and infant characteristics associated with a GV and caloric intake in the lowest quartile. Results: Newborns in the lowest gestational age and low birth weight categories, as well as those with intrauterine growth restriction, or high SNAP-II received relatively fewer kcal/kg/day than their peers without these risk factors, but were not at increased risk of being in the lowest GV quartile. Newborns with bacteremia, patent ductus arteriosus, retinopathy of prematurity stage 3-5, or pulmonary illness received fewer calories, as did those who received medications or blood transfusions. However, in a multivariable model adjusting for confounders, only ventilator dependence on day 7 (OR 2.2, 95% CI 1.5-3.2), early persistent pulmonary dysfunction (OR 1.8, 95% CI 1.3-2.5), and postnatal exposure to dexamethasone (OR 2.8, 95% CI 1.2-6.5) were associated with an increased risk of being in the lowest GV quartile. In this model, low caloric intake was not associated with low GV (OR 1.3, 95% CI 0.9-1.9). Conclusion: Variables associated with severe pulmonary disease convey more information about the risk of reduced GV during the first 28 postnatal days than does low caloric intake. |
| Databáze: | OpenAIRE |
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