Correlation between pentosidine and endothelin-1 in subjects undergoing chronic hemodialysis
| Autor: | Tommaso Barreca, Cristina Robaudo, Fiammetta Monacelli, Daniela Storace, Giacomo Deferrari, Patrizio Odetti, S Rossi |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty endotelina Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry emodialisi cronica pentosidina Arginine Biochemistry Pathogenesis chemistry.chemical_compound Endocrinology Glycation Renal Dialysis Internal medicine medicine Humans Chronic hemodialysis Pentosidine Endothelial dysfunction glicossidazione Endothelin-1 business.industry Lysine Biochemistry (medical) General Medicine Middle Aged medicine.disease Endothelin 1 Uremia chemistry Case-Control Studies Kidney Failure Chronic Female Hemodialysis business |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 38(12) |
| ISSN: | 0018-5043 |
| Popis: | Advanced glycation end-products (AGEs), which accumulate in the blood and tissues of patients with chronic renal failure (CRF) undergoing chronic hemodialysis, play an important role in the pathogenesis of uremic complications. Endothelin 1 (ET1), a 21-amino acid peptide with vasoconstricting and mitogenic properties, is an important factor in the endothelial dysfunction occurring in uremia. The circulating levels of both AGEs and ET1 have been reported to be increased in chronic renal failure. In the present study we evaluated the possible relationship between pentosidine and ET1 plasma levels in CRF patients undergoing chronic hemodialysis treatment. The plasma concentrations of "free" and bound pentosidine (HPLC methods) and endothelin-1 (RIA method) were measured before the hemodialysis session in 40 nondiabetic CRF patients (22 males and 18 females; 54+/-3 years) on chronic hemodialysis for at least 1 year. Forty age- and sex-matched normal subjects served as a control group. In hemodialyzed patients, the overall pentosidine residues and pentosidine-free adduct plus pentosidine-free adduct bound reversibly to protein levels (24.9+/-2.04 pmol/mg protein and 110.5+/-5.9 pmol/ml, respectively) were significantly higher than those recorded in normal subjects (2.0+/-0.2 pmol/mg protein and 0.7+/-0.2 pmol/ml, respectively ). Endothelin-1 was also significantly (p |
| Databáze: | OpenAIRE |
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