Study of an inhibiting factor of epidermal proliferation in plucked skin and various tumours of mice
| Autor: | E. Frindel, M. Tubiana, M. Guigon, J. Hewitt |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms Lymphoma Dermatology Biology Inhibitory postsynaptic potential Mice chemistry.chemical_compound Skin tumours Skin Physiological Phenomena Mitotic Index medicine Animals Inhibitory effect Skin Mice Inbred C3H Wound Healing integumentary system Experimental model Mesenchymal stem cell Mammary Neoplasms Experimental Neoplasms Experimental Growth Inhibitors chemistry Normal skin Thymidine |
| Zdroj: | British Journal of Dermatology. 95:131-135 |
| ISSN: | 1365-2133 0007-0963 |
| Popis: | SUMMARY The aim of our research was to investigate, by autoradiographic meAods, the presence of an inhibitory factor (IF) in normal skin, in plucked skin and in five experimental skin tumours of the mouse, capable of inhibiting epidermal proliferation. The experimental model used was that of BuUough & Laurence (1960), i.e. a wound in the ear of a mouse. After tritiated thymidine administration the measurement of the labelling index confirmed the existence of an inhibitory substance in normal skin. The plucked skin had no inhibitory effect when it was taken 24 h after plucking, but after 4 days its effect had returned to normal. The skin tumours, whether epithelial or mesenchymal, showed the same inhibitory effect as normal skin whereas a non-cutaneous tumour tested had no inhibitory effect. |
| Databáze: | OpenAIRE |
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