Diabetic vascular disease: it's all the RAGE
| Autor: | Loredana G. Bucciarelli, Barry I. Hudson, Shi Fang Yan, Yoshifumi Naka, Ling Ling Rong, Thoralf Wendt, Ann Marie Schmidt |
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| Rok vydání: | 2005 |
| Předmět: |
Glycation End Products
Advanced medicine.medical_specialty endocrine system diseases Physiology Clinical Biochemistry Receptor for Advanced Glycation End Products Disease Diabetic angiopathy Biochemistry Proinflammatory cytokine RAGE (receptor) Glycation Internal medicine Diabetes mellitus Medicine Animals Humans Receptors Immunologic Molecular Biology General Environmental Science business.industry Vascular disease nutritional and metabolic diseases Cell Biology medicine.disease Blockade Endocrinology Hyperglycemia Immunology Disease Progression General Earth and Planetary Sciences business Diabetic Angiopathies Signal Transduction |
| Zdroj: | Antioxidantsredox signaling. 7(11-12) |
| ISSN: | 1523-0864 |
| Popis: | The major consequence of long-term diabetes is the increased incidence of disease of the vasculature. Of the underlying mechanisms leading to disease, the accumulation of advanced glycation end products (AGEs), resulting from the associated hyperglycemia, is the most convincing. Interaction of AGEs with their receptor, RAGE, activates numerous signaling pathways leading to activation of proinflammatory and procoagulatory genes. Studies in rodent models of macro- and microvascular disease have demonstrated that blockade of RAGE can prevent development of disease. These observations highlight RAGE as a therapeutic target for treatment of diabetic vascular disease. |
| Databáze: | OpenAIRE |
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