Evaluating the Survival Benefit of Kidney Retransplantation
| Autor: | Stanley S. A. Fenton, Panduranga S. Rao, Guanghui Wei, Douglas E. Schaubel |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Reoperation Canada medicine.medical_specialty Adolescent medicine.medical_treatment Internal medicine medicine Humans Registries Renal replacement therapy Kidney transplantation Dialysis Survival analysis Proportional Hazards Models Transplantation Kidney business.industry Proportional hazards model Mortality rate Hazard ratio Middle Aged medicine.disease Kidney Transplantation Survival Analysis medicine.anatomical_structure Female business |
| Zdroj: | Transplantation. 82:669-674 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/01.tp.0000235434.13327.11 |
| Popis: | BACKGROUND: The magnitude of the survival benefit associated with kidney retransplantation has not been well studied. METHODS: Using data from the Canadian Organ Replacement Register (CORR), we studied patients (n=3,067) initiating renal replacement therapy during 1981-1998 who had received a transplant and experienced graft failure (GF). Such patients were followed until death, loss to follow-up or the end of the observation period (December 31, 1998). Using Cox regression, we estimated the post-GF covariate-adjusted hazard ratio (HR) for retransplant versus dialysis, and determined whether the contrast differed across patient subgroups. Through nonproportional hazards models, we also examine patterns in the retransplant/dialysis HR with time following retransplant. RESULTS: Overall, retransplantation is associated with a covariate-adjusted 50% reduction in mortality, relative to remaining on dialysis (HR=0.50; P |
| Databáze: | OpenAIRE |
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