Clinical analysis of 11 cases of nocardiosis
| Autor: | Ting Tang, Li-Ping Ma, Yiqing Li, Boqi Li, Jieyu Wang, Jie Xiao, Danian Nie, Shuangfeng Xie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pediatrics medicine.drug_class diagnosis 030106 microbiology Antibiotics Avascular necrosis Malignancy immunosuppressive agents 03 medical and health sciences Femoral head 0302 clinical medicine medicine therapeutics 030212 general & internal medicine Nocardia infections Bronchiectasis Clinical pathology business.industry Nocardiosis General Medicine medicine.disease Pneumonia medicine.anatomical_structure Medicine business Research Article |
| Zdroj: | Open Medicine Open Medicine, Vol 16, Iss 1, Pp 610-617 (2021) |
| ISSN: | 2391-5463 |
| Popis: | Nocardiosis is a rare, life-threatening, opportunistic, and suppurative infection. Its clinical manifestation lacks specificity, which makes early diagnosis difficult. A retrospective analysis of the clinical records of 11 patients with nocardiosis admitted to our hospital from January 2013 to November 2018 was conducted. All patients had at least one underlying disorder, such as an autoimmune disease (6/11), a blood malignancy (2/11), avascular necrosis of the femoral head (1/11), bronchiectasis (1/11), or pneumonia (1/11). The first-line treatment was trimethoprim–sulfamethoxazole (TMP–SMX); one or two additional antibiotics were given according to the drug-sensitive test. The median time from onset to treatment was 3 weeks (ranging from 1 to 9 weeks). The median duration of treatment after diagnosis was 20.5 weeks (ranging from 7 to 47 weeks). Eight patients were discharged and survived, and three patients died. This indicates that early use of TMP–SMX combined with sensitive antibiotics could improve the condition of patients and improve the cure rate (8/11). Clinically, it is necessary to consider the possibility of nocardiosis in patients with long-term use of immunosuppressants and poor response to treatment of common bacterial infections. Early diagnosis, timely treatment, and combination drug therapy are keys to improving the outcomes of patients with nocardiosis. |
| Databáze: | OpenAIRE |
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