ANTIGENICITY STUDY OF TRANDOLAPRIL (RU44570)
| Autor: | Hiroshi Wada, Masami Kato, Fumihiko Aruga, Yoshiaki Hongo, Roza Ishihara, Sakae Iwasaki, Yasushi Yamada |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Trandolapril Antigenicity Indoles Guinea Pigs Angiotensin-Converting Enzyme Inhibitors Ileum Pharmacology Toxicology Drug Hypersensitivity Rats Sprague-Dawley Guinea pig Mice chemistry.chemical_compound Immune Tolerance medicine Animals Intradermal injection Anaphylaxis Mice Inbred BALB C Mice Inbred C3H business.industry medicine.disease Rats Titer medicine.anatomical_structure chemistry Immunology Female business Histamine medicine.drug |
| Zdroj: | The Journal of Toxicological Sciences. 18:161-175 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.18.supplementi_161 |
| Popis: | Antigenicity of trandolapril (RU44570) was evaluated using the following six standpoints: 1. active systemic anaphylaxis (ASA) in guinea pigs; 2. passive cutaneous anaphylaxis (PCA) in guinea pigs with serum of sensitized guinea pigs; 3. histamine release from lung tissue of sensitized guinea pigs; 4. Schultz-Dale reaction with isolated ileum of sensitized guinea pigs; 5. passive cutaneous anaphylaxis (PCA) in rats with serum of sensitized mice; and 6. delayed type skin reaction by Maximization test in guinea pigs. In the test of immediate type reactions, guinea pigs were sensitized by RU44570 (p.o.), an FCA emulsion of RU44570 (s.c.) or an FCA emulsion of incubate solution of RU44570 and normal guinea pig's serum, and mice were sensitized by a mixture of RU44570 and alum (i.p.). In the test of delayed type reaction, guinea pigs were sensitized by intradermal injection and patch application. 1. ASA in guinea pigs: No anaphylaxis symptoms were observed in any of the sensitized guinea pigs. 2. PCA in guinea pigs: PCA titer of sera from all the sensitized animals was less than 1. 3. Histamine release from lung tissue: No histamine release was observed in any of the isolated lung tissue. 4. Schultz-Dale reaction: No contraction was observed in any of the isolated ileums. 5. PCA in rats: PCA titer of sera from sensitized BALB/c and C3H/He mice was less than 5. 6. Delayed type skin reaction test: No skin reactions were observed in any of the sensitized guinea pigs. From these results, it is concluded that RU44570 has no antigenicity under the conditions of the present study. |
| Databáze: | OpenAIRE |
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