Captopril improves hemodynamic response to static exercise in patients with congestive heart failure: a double-blind, placebo-controlled, randomized trial
Autor: | Ettore Ambrosioni, F. V. Costa, Borgi C, Bruno Magnani, Carlo Magelli |
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Rok vydání: | 1990 |
Předmět: |
Male
medicine.medical_specialty Captopril Diastole Hemodynamics Physical exercise Blood Pressure Isometric exercise Placebos Double-Blind Method Heart Rate Internal medicine medicine Humans Exercise Randomized Controlled Trials as Topic Heart Failure business.industry Muscles General Medicine Middle Aged medicine.disease Myocardial Contraction Forearm Endocrinology medicine.anatomical_structure Blood pressure Heart failure Cardiology Vascular resistance Female Vascular Resistance Cardiology and Cardiovascular Medicine business medicine.drug Muscle Contraction |
Zdroj: | Clinical cardiology. 13(5) |
ISSN: | 0160-9289 |
Popis: | Systemic and peripheral hemodynamic response to isometric exercise by handgrip test at 30% maximal voluntary contraction (MVC) for 3 minutes was assessed in 16 patients with congestive heart failure (CHF) after short-term treatment with either captopril or placebo given according to a double-blind, randomized, cross-over sequence. During placebo, isometric exercise increased blood pressure (BP) and total peripheral vascular resistance (TPVR) and decreased cardiac index (CI). Captopril reduced the pressor response to exercise (mean +/- SD) (% systolic: from 14.7 +/- 6 to 11.7 +/- 3; p less than .05/% diastolic: from 12.4 +/- 4 to 8 +/- 3; p less than .005) and increased CI (from 2.3 +/- .6 to 2.6 +/- .9 liters/min/m2; p less than .01) whereas TPVR remained virtually unchanged (from 1479 +/- 597 to 1594 +/- 692 U; NS). The changes in mean BP after exercise were inversely related to the early increase in forearm blood flow (FBF) in exercising forearm during both placebo (r = .67) and captopril (r = .71). The extent of reduction in mean BP response after captopril was inversely related to the extra increase in exercising FBF determined by the drug when compared to placebo (r = .73). We conclude that captopril is able to improve the hemodynamic response to static exercise in patients with CHF, probably by increasing the blood supply to exercising muscles during contraction, thus blunting the extent of reflex pressor response. |
Databáze: | OpenAIRE |
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