No Influence of Aging on the Circadian Rhythm of Erythropoietin in Healthy Subjects

Autor:	Raffaele Casale, Paolo Pasqualetti
Rok vydání:	1997
Předmět:	Adult Male Senescence Aging medicine.medical_specialty Chronobiology Healthy subjects Middle Aged Biology Circadian Rhythm Endocrinology Erythropoietin hemic and lymphatic diseases Internal medicine medicine Humans Female Circadian rhythm Geriatrics and Gerontology Aged medicine.drug
Zdroj:	Gerontology. 43:206-209
ISSN:	1423-0003 0304-324X
DOI:	10.1159/000213851
Popis:	The diurnal rhythm in the circulating serum levels of erythropoietin (Epo) was investigated in a group of 20 clinically healthy subjects aged 30-55 years and in a group of 20 healthy subjects aged 55-75 years. Venous blood samples were drawn during the span of a whole day every 4 h, starting from midnight, for the determination of serum Epo levels by radioimmunoassay. Statistical analysis was carried out by means of the 'cosinor' method. Both groups presented a significant (p0.05) circadian rhythm in serum Epo levels, with maximum in the afternoon. The younger subjects had significantly (p0.05) higher mean daily levels and higher diurnal variations of serum Epo than older subjects; no difference (p0.05) was found between the groups regarding the peaks of the rhythms. These data confirm the presence of a circadian rhythm in serum EPO levels and suggest that the aging process does not influence the physiological diurnal fluctuations but modifies the mean daily levels and the amplitude of the diurnal variations, such as it occurs for many other variables. This behavior is an index of aging, but does not seem to have clinical implications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14634830efda6d92c5026eeaeb50d9aa https://doi.org/10.1159/000213851 Zobrazit plný text záznamu