Regulation of Optic Nerve Head Blood flow in Normal Tension Glaucoma Patients
| Autor: | P. De Gottrau, C.E. Riva, H. Bresson-Dumont, A. Bechetoille, Constantin J. Pournaras |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure genetic structures Optic Disk Optic disk Blood Pressure Isometric exercise 03 medical and health sciences 0302 clinical medicine Normal tension glaucoma Internal medicine Laser-Doppler Flowmetry medicine Humans Exercise Intraocular Pressure Aged Aged 80 and over business.industry General Medicine Blood flow Middle Aged eye diseases Ophthalmology Blood pressure medicine.anatomical_structure Regional Blood Flow Anesthesia 030221 ophthalmology & optometry Cardiology Vascular resistance Female sense organs business Perfusion Blood Flow Velocity Glaucoma Open-Angle 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Ophthalmology. 14:226-235 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/112067210401400307 |
| Popis: | Purpose To investigate the regulation of the optic nerve blood flow (Fonh) in response to an increase of the perfusion pressure (PPm) in normal tension glaucoma (NTG) patients and in age-matched normal volunteers. METHODS Measurements were performed in 16 eyes of NTG patients and in 10 eyes of age-matched controls. Laser Doppler flowmetry (LDF) was applied to calculate the relative flux of red blood cells at the temporal rim of the optic nerve head (ONH) in response to increases in PPm. PPm was raised through an increase in systemic blood pressure induced by isometric exercise. Before being tested, all patients had 3 weeks of washout of any local medication. Results In the NTG group, mean ophthalmic arterial blood pressure increased during isometric exercise from 73 to 89 mmHg (22%), resulting in a 29% increase of the PPm. This increase did not induce any significant change in mean Fonh. For the control group, the 28% increase of PPm also did not significantly affect Fonh. There was a trend for a greater increase in vascular resistance during isometric exercise in the NTG than in the normal control group (47% versus 25%). CONCLUSIONS The LDF parameters, measured in the ONH, did not indicate an abnormal Fonh regulation in response to an increase of the PPm in either normal subjects or NTG patients. The maintenance of constant blood flow is achieved by an increase in local vascular resistance. Our data show a greater percent increase in vascular resistance in the NTG patients compared to the normal subjects for a similar percent increase in PPm in both groups during squatting. This suggests some alteration of the vessel tone regulatory mechanisms in NTG patients. |
| Databáze: | OpenAIRE |
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