Colorectal cancer: Greater neo-angiogenesis, less perforation, worst oncological outcomes
| Autor: | Gianluca Costa, Pietro Fransvea, Gabriele Sganga |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Neo angiogenesis medicine.medical_specialty Neovascularization Pathologic Colorectal cancer business.industry Angiogenesis Perforation (oil well) Aggressive cancer General Medicine medicine.disease Medical Oncology 03 medical and health sciences Tumor perforation 030104 developmental biology 0302 clinical medicine Intestinal Perforation Internal medicine Colonic Neoplasms medicine Humans business Colorectal Neoplasms 030217 neurology & neurosurgery |
| Zdroj: | Medical hypotheses. 146 |
| ISSN: | 1532-2777 |
| Popis: | Little attention has been paid to the anatomopathological factors and pathophysiologic mechanisms involved in CRC perforation. Perforation is one of the most serious complications occurring up to 11% of the cases and may also be the first manifestation of the tumor. Differentiation and angiogenesis have an important role in the tumor perforation mechanism. On the one hand, a greater expression of vascularization optimizes the supply of oxygen to the tumor and thus entails a lower necrotic wall rate and thus of perforation, on the other it is associated with a lower rate of differentiation and hence to a more aggressive cancer cells. |
| Databáze: | OpenAIRE |
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