Concurrent chemotherapy and radiation therapy in advanced head and neck cancer
| Autor: | P.G. Shankar Giri, Sarah A. Taylor |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Vincristine Time Factors Pulmonary toxicity medicine.medical_treatment Bleomycin chemistry.chemical_compound Antineoplastic Combined Chemotherapy Protocols medicine Mucositis Humans Laryngeal Neoplasms Chemotherapy Hypopharyngeal Neoplasms business.industry Head and neck cancer Radiotherapy Dosage medicine.disease Combined Modality Therapy Surgery Radiation therapy Oropharyngeal Neoplasms Peripheral neuropathy Oncology chemistry Head and Neck Neoplasms Carcinoma Squamous Cell Mouth Neoplasms Cisplatin business medicine.drug Follow-Up Studies |
| Zdroj: | American journal of clinical oncology. 10(5) |
| ISSN: | 0277-3732 |
| Popis: | A combination of radiation therapy and cis-platinum (25 mg/m2 i.v.) day 1, vincristine (1 mg i.v.) day 2, and bleomycin (15 U i.v.) day 4 was given concomitantly to 14 patients with advanced inoperable head and neck cancer and one patient with local recurrence. Radiation therapy consisted of 70 Gy to the involved areas and 50 Gy to adjacent uninvolved areas at 1.8 Gy per fraction. The overall response rate was 100%. Nine patients (60%) achieved a complete response, and six patients achieved a partial response. One patient appeared to have increasing disease, but biopsies have shown only fibrosis. The survival is 8 of 15 (53%), with a median follow-up time of 24 months. Most significant toxicity was anorexia and weight loss. Other toxicity consisted of peripheral neuropathy (1 patient), mild transient elevation of creatinine (1 patient), hypothyroidism (1 patient), and mild pulmonary toxicity (2 patients). Mucositis occurred in all patients, requiring interruption of therapy (2-14 days). |
| Databáze: | OpenAIRE |
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