Role of the oxidative stress index, myeloperoxidase, catalase activity for cardiac allograft vasculopathy in heart transplant recipients

Autor:	Şeyhmus Külahçıoğlu, Mehmet Çelik, Aybala Erek Toprak, Mehmet Aytürk, Mustafa Bulut, Mehmet Yunus Emiroglu, Mert Evlice, Ramazan Kargin, Anıl Avcı, Mustafa Caliskan
Rok vydání:	2018
Předmět:	0301 basic medicine Adult Male medicine.medical_specialty Arbitrary unit 030204 cardiovascular system & hematology medicine.disease_cause Cardiac allograft vasculopathy Gastroenterology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Vascular Diseases Male gender Peroxidase Transplantation Univariate analysis biology business.industry Middle Aged Allografts Catalase Prognosis Antioxidant capacity Oxidative Stress 030104 developmental biology Myeloperoxidase cardiovascular system biology.protein Heart Transplantation Female business Oxidative stress Follow-Up Studies
Zdroj:	Clinical transplantation. 32(7)
ISSN:	1399-0012
Popis:	BACKGROUND The aim of this study was to explore the role of oxidative stress index (OSI), myeloperoxidase (MPO), and catalase (CAT) activity in cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTRs). METHODS The study enrolled a median age of 41 ± 9 years 47 recipients. The HTx patients were divided into two groups based on the presence CAV as follows: CAV(+) and CAV(-) group. Also, CAV(+) group were divided into two groups as mild/moderate to severe CAV. The OSI, MPO, and CAT activity were analyzed in both groups. RESULTS The mean total antioxidant capacity (0.79 ± 0.46 vs 1.03 ± 0.33 μmol H2 O2 equiv/L) P = .043 was significantly lower and OSI, MPO, CAT activity were significantly higher in CAV(+) group (63 ± 38 vs 20 ± 16 arbitrary unit, P = .001; 398 ± 242 vs 139 ± 112 μg/L, P = .001; 51 ± 42 vs 26 ± 23 pmol/mg protein, P = .013, respectively). Also, mean OSI (38 ± 41 vs 93 ± 75, P = .05) were significantly higher in severe CAV(+) group. Recipient age, male gender, and low density lipoprotein-cholesterol were significantly higher in CAV(+) group. There was a moderate correlation between the CAV grade and OSI, MPO, and CAT levels in univariate analysis (r = .560, P = .002; r = .643, P = .007; r = .681, P = .001, respectively). CONCLUSION An increase in the serum level of OSI, MPO, and CAT was associated with CAV in HTRs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145b9bc72cd634b0a4a34b2d243b6753 https://pubmed.ncbi.nlm.nih.gov/29923227 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.