Effectiveness of N95 respirators versus surgical masks against influenza: A systematic review and meta-analysis
Autor: | Qiong Guo, Rui Chen, Jin Huang, Liang Du, Tengyue Hu, Liu Yang, Youlin Long, Liqin Liu, Yifan Cheng |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
business.product_category masks respiratory tract infections Cochrane Library Article law.invention 03 medical and health sciences 0302 clinical medicine respiratory protective devices Randomized controlled trial law Internal medicine surgical mask Influenza Human medicine Humans 030212 general & internal medicine Respirator Randomized Controlled Trials as Topic Respiratory tract infections business.industry Health Policy Respiratory infection General Medicine Articles N95 respirator Surgical mask Systematic review Meta-analysis business influenza 030217 neurology & neurosurgery |
Zdroj: | Journal of Evidence-Based Medicine |
ISSN: | 1756-5391 |
Popis: | Objective Previous meta‐analyses concluded that there was insufficient evidence to determine the effect of N95 respirators. We aimed to assess the effectiveness of N95 respirators versus surgical masks for prevention of influenza by collecting randomized controlled trials (RCTs). Methods We searched PubMed, EMbase and The Cochrane Library from the inception to January 27, 2020 to identify relevant systematic reviews. The RCTs included in systematic reviews were identified. Then we searched the latest published RCTs from the above three databases and searched ClinicalTrials.gov for unpublished RCTs. Two reviewers independently extracted the data and assessed risk of bias. Meta‐analyses were conducted to calculate pooled estimates by using RevMan 5.3 software. Results A total of six RCTs involving 9 171 participants were included. There were no statistically significant differences in preventing laboratory‐confirmed influenza (RR = 1.09, 95% CI 0.92‐1.28, P > .05), laboratory‐confirmed respiratory viral infections (RR = 0.89, 95% CI 0.70‐1.11), laboratory‐confirmed respiratory infection (RR = 0.74, 95% CI 0.42‐1.29) and influenzalike illness (RR = 0.61, 95% CI 0.33‐1.14) using N95 respirators and surgical masks. Meta‐analysis indicated a protective effect of N95 respirators against laboratory‐confirmed bacterial colonization (RR = 0.58, 95% CI 0.43‐0.78). Conclusion The use of N95 respirators compared with surgical masks is not associated with a lower risk of laboratory‐confirmed influenza. It suggests that N95 respirators should not be recommended for general public and nonhigh‐risk medical staff those are not in close contact with influenza patients or suspected patients. |
Databáze: | OpenAIRE |
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