CAPTOPRIL DOES NOT POTENTIATE HYPOTENSION AND ALGESIA BY SUBSTANCE P
| Autor: | S.-C. G. Hui, Clive W. Ogle |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Captopril Physiology Blood Pressure Substance P Drug synergism Mice chemistry.chemical_compound In vivo Physiology (medical) Internal medicine Animals Medicine cardiovascular diseases Pharmacology Mice Inbred ICR Hyperesthesia business.industry Drug Synergism Rats Inbred Strains Algesia Rats Blood pressure Nociception Endocrinology chemistry Hyperalgesia Hypotension medicine.symptom business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 13:819-822 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1986.tb02386.x |
| Popis: | Captopril (1-5 mg/kg, i.v.) did not affect the vasodepressor responses to substance P (1-30 micrograms/kg, i.v.) in anaesthetized rats. Substance P (100 micrograms/kg, s.c.) produced significant algesia in mice; this was not potentiated by the smaller doses of captopril (1-2 mg/kg, i.p.), but was instead antagonized by the high dose (5 mg/kg, i.p.). It is concluded that captopril does not have any influence on substance P degradation in vivo since the pharmacological actions of the undecapeptide are not enhanced after captopril treatment. |
| Databáze: | OpenAIRE |
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