Red Blood Cell Transfusion Guided by Near Infrared Spectroscopy in Neurocritically Ill Patients with Moderate or Severe Anemia: A Randomized, Controlled Trial
Autor: | Victoria Arellano-Orden, Antonio Marín-Caballos, Reginald Dusseck, Manuel Casado-Méndez, Rosario Amaya-Villar, C. García-Alfaro, Santiago R. Leal-Noval, Manuel Muñoz-Gómez, Francisco Murillo-Cabezas, Aurelio Cayuela, M.D. Rincón-Ferrari |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male Subarachnoid hemorrhage Anemia Traumatic brain injury Red Blood Cell Transfusion Severity of Illness Index law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Brain Injuries Traumatic Outcome Assessment Health Care Medicine Humans Oxygen saturation (medicine) Intracerebral hemorrhage Spectroscopy Near-Infrared business.industry 030208 emergency & critical care medicine Middle Aged medicine.disease Neurophysiological Monitoring Anesthesia Female Neurology (clinical) Hemoglobin business Erythrocyte Transfusion Intracranial Hemorrhages 030217 neurology & neurosurgery |
Zdroj: | Journal of neurotrauma. 34(17) |
ISSN: | 1557-9042 |
Popis: | In neurocritically ill patients (NCPs), the use of hemoglobin level as the sole indicator for red blood cell transfusion (RBCT) can result in under- or over-transfusion. This randomized controlled trial was conducted to ascertain whether a transcranial oxygen saturation (rSO2) threshold, as measured by near-infrared spectroscopy, reduces RBCT requirements in anemic NCPs (closed traumatic brain injury, subarachnoid, or intracerebral hemorrhage), compared with a hemoglobin threshold alone. Patients with hemoglobin 70–100 g/L received RBCTs to attain an rSO2 > 60% (rSO2 arm) or to maintain hemoglobin between 85 and 100 g/L (hemoglobin arm). A total of 102 NCPs (51 in each group) were included in the intention-to-treat analysis, and 97 were included in the per-protocol analysis (51 and 46, respectively). Compared with those from the hemoglobin arm, patients in rSO2 arm received fewer RBC units (1.0 ± 0.1 vs. 1.5 ± 1.4 units/patient; p |
Databáze: | OpenAIRE |
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