Red Blood Cell Transfusion Guided by Near Infrared Spectroscopy in Neurocritically Ill Patients with Moderate or Severe Anemia: A Randomized, Controlled Trial

Autor: Victoria Arellano-Orden, Antonio Marín-Caballos, Reginald Dusseck, Manuel Casado-Méndez, Rosario Amaya-Villar, C. García-Alfaro, Santiago R. Leal-Noval, Manuel Muñoz-Gómez, Francisco Murillo-Cabezas, Aurelio Cayuela, M.D. Rincón-Ferrari
Rok vydání: 2017
Předmět:
Zdroj: Journal of neurotrauma. 34(17)
ISSN: 1557-9042
Popis: In neurocritically ill patients (NCPs), the use of hemoglobin level as the sole indicator for red blood cell transfusion (RBCT) can result in under- or over-transfusion. This randomized controlled trial was conducted to ascertain whether a transcranial oxygen saturation (rSO2) threshold, as measured by near-infrared spectroscopy, reduces RBCT requirements in anemic NCPs (closed traumatic brain injury, subarachnoid, or intracerebral hemorrhage), compared with a hemoglobin threshold alone. Patients with hemoglobin 70–100 g/L received RBCTs to attain an rSO2 > 60% (rSO2 arm) or to maintain hemoglobin between 85 and 100 g/L (hemoglobin arm). A total of 102 NCPs (51 in each group) were included in the intention-to-treat analysis, and 97 were included in the per-protocol analysis (51 and 46, respectively). Compared with those from the hemoglobin arm, patients in rSO2 arm received fewer RBC units (1.0 ± 0.1 vs. 1.5 ± 1.4 units/patient; p
Databáze: OpenAIRE